Evaluation of Ketamine and Multi-modal Analgesics for Postoperative Analgesia, Opioid Sparing, and Early Extubation in ICU Compared With Conventional Analgesia
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Changes between the two groups assessed by overall ventilator days
研究概览
简要总结
The purpose of this research study is to see if pain can be better controlled with fewer side effects. The new drug regimen will study several different medicines that have different ways of treating pain.
详细描述
The investigators plan to study an analgesic regimen of Ketamine and Lidocaine as infusions with Neurontin and acetaminophen delivered orally for postoperative analgesia and the subsequent effect on ventilator days and ICU stay. The investigators expect that pain scores will be either unchanged or better than historic controls. In addition, the investigators expect that ventilator days and ICU stay will be improved due to reduced incidence of delirium and bowel dysfunction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) status 1-4
- •Undergoing planned surgery for cardiac problems
- •18 years of age and not older than 85 years of age
排除标准
- •Severe liver disease (alanine aminotransferase (ALT) , aspartate aminotransferase (AST), or bilirubin > 2.5 times Upper Limit of Normal)
- •Pregnancy or currently breastfeeding
- •History of schizophrenia or other hallucinatory psychiatric disorder
- •History of chronic or pre-existing pain disorder
- •History of heart block
- •Severe renal impairment Creatinine Clearance (CrCl)<30 milliliter(mL)/min
研究组 & 干预措施
Study Group
The investigators plan to study an analgesic regimen of Ketamine and lidocaine as infusions with Neurontin and Acetaminophen delivered orally for postoperative analgesia and the subsequent effect on ventilator days and ICU stay.
干预措施: Ketamine (Drug)
Study Group
The investigators plan to study an analgesic regimen of Ketamine and lidocaine as infusions with Neurontin and Acetaminophen delivered orally for postoperative analgesia and the subsequent effect on ventilator days and ICU stay.
干预措施: Lidocaine (Drug)
Study Group
The investigators plan to study an analgesic regimen of Ketamine and lidocaine as infusions with Neurontin and Acetaminophen delivered orally for postoperative analgesia and the subsequent effect on ventilator days and ICU stay.
干预措施: Acetaminophen (Drug)
Study Group
The investigators plan to study an analgesic regimen of Ketamine and lidocaine as infusions with Neurontin and Acetaminophen delivered orally for postoperative analgesia and the subsequent effect on ventilator days and ICU stay.
干预措施: Neurontin (Drug)
结局指标
主要结局
Changes between the two groups assessed by overall ventilator days
时间窗: Through study completion, an average of one week
Total ventilator days
次要结局
- Changes between the two groups assessed by ICU length of stay(Through study completion, an average of one week)