Correlation of High Resolution Esophageal Manometry With Symptoms
- Conditions
- Post FundoplicationAchalasiaChest PainDysphagiaGERD
- Interventions
- Procedure: High Resolution Manometry
- Registration Number
- NCT01202929
- Lead Sponsor
- University of Louisville
- Brief Summary
High Resolution Manometry is a new technology that utilizes 36 solid state sensors on a thin catheter spaced at 1-cm intervals. One can more effectively measure the pressure of the esophagus. It includes a sophisticated software to display the pressures data as color topography plot using time, length of the esophagus and pressure within the entire esophagus. It is unclear if this technology improvement actually correlates with patient's symptoms.
- Detailed Description
In a 2007 retrospective study performed using this technology, 400 subjects referred to the motility lab underwent high resolution manometry (HRM) for complaints of dysphasia, gastroesophageal reflux disease, chest pain and miscellaneous complaints. HRM offered greater detail of individual contracting segments of the esophagus, including the duration of contraction and propagation of individual contractions.
For example, a new subclass of achalasia was defined by HRM. In this classification, achalasia is divided into types 1, 2 and 3. Type 1 corresponds to classic achalasia (complete esophageal motor failure), type 2 is a compression achalasia (simultaneous panesophageal pressurization with aperistalsis), and type 3 is spastic achalasia with aperistalsis (100% spasm). However, it is unclear if this categorization represents a spectrum of disease among patients with achalasia, or it represents distinct subgroups of patients with different symptom presentation and etiology.
This study will attempt to correlate the data from HRM to patient's chief compliants, symptom severity, and clinical presentation.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- Subjects who are referred to the motility lab to undergoing esophageal HRM for various clinical indications.
- Pregnancy
- Unable to give consent
- Less than 18 years old
- Prisoner
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Type I achalasia High Resolution Manometry classic achalasia: complete esophageal motor failure Type III achalasia High Resolution Manometry spastic achalasia with aperistalsis: 100% spasm Type II achalasia High Resolution Manometry compression achalasia: simultaneous panesophageal pressurization with aperistalsis
- Primary Outcome Measures
Name Time Method Differences and similarities in patients with achalasia at 24 months To determine the differences and similarities in the clinical presentation of patients with type 1, 2 and 3 achalasia based on the Chicago classification for HRM
- Secondary Outcome Measures
Name Time Method Esophageal dysmotility in patients with postfundoplication compliants at 24 months To determine the prevalence of esophageal dysmotility using the Chicago classification based in patients with postfundoplication complaints.
HRM parameters at 24 months To determine if HRM parameters reflect esophageal physiology between contractile strength of the esophagus and GEJ residual pressure obstructing esophageal flow.
Correlation between HRM and symptoms At 24 months To determine if HRM parameters reflect symptom presentations.
Esophageal dysmotility in patients with dysphagia and GERD symptoms at 24 months To determine the prevalence of esophageal dysmotility using the Chicago classification based on primary chief complaints.
Trial Locations
- Locations (1)
University of Louisville
🇺🇸Louisville, Kentucky, United States