Comparison of analgesic effect of dexemedetomidine & ketamine with dexemedetomidine in mechanically ventilated patients

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/06/054139
• Lead Sponsor: Dr Babaloo Kumar Singh

Brief Summary

The objective of this study is to evaluate dexmedetomidine in comparison to combination of ketamine and dexmedetomidine (KETODEX) in analgesia for elective post-operative mechanical ventilation after major surgery . We also want to compare time to extubation, duration of ICU stay, pain scores, side effect profiles, and patient satisfaction with the two regimens.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-06-17
• Study Start: 2023-06-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1.Patients of ASA physical status 1 and 2 2.Patients between 18-60 years of age of either sex 3.Patients undergoing major abdominal surgery shifted to the ICU for elective ventilation.

Exclusion Criteria

• 1.Patients who were pregnant or nursing; or had abnormal laboratory test results, significant psychiatric, neurological, cardiovascular, renal, or hepatic diseases.
• 2.Patients on Neuromuscular blocking agents.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of Dexmedetomidine with combination of ketamine & dexmedetomidine in analgesia for elective post-operative mechanical ventilation after major surgery Analgesia defined as BPS score 5.	1 year

Secondary Outcome Measures

Name	Time	Method
Sedation score (till extubation)	Time to Extubation

Trial Locations

Locations (1)

Indira Gandhi Institute of Medical Sciences, Patna; 🇮🇳 Patna, BIHAR, India

Indira Gandhi Institute of Medical Sciences, Patna

🇮🇳Patna, BIHAR, India

Dr Babaloo kumar Singh

Principal investigator

8252631393

bablu2k10skmc@gmail.com