Single Centric Non- Randomized Open Clinical Trial Phase II in Karathambam among Madhumegam patients ( Diabetic Neuropathy ) with siddha medicine Brahmi nei among patients attending OPD at Government Siddha Medical College Hospital, Chennai

Peripheral neuropathies are diseases of the peripheral nervous system that can be divided into mononeuropathies, multifocal neuropathies, and polyneuropathies.

The first symptoms tend to be sensory and consists of tingling, prickling, burning or bandlike dysesthesias in the balls of the feet or tip of the toes or in a general distribution over the soles.The tingling sensation started distally and limited in the “Glove and stocking” distribution.Peripheral Neuropathy may be due to various cause Hereditary, Metabolic causes,

Nutritional Deficiency, Connective tissue disorders, Infection, Toxins and Malignancy.

Diabetic Neuropathy is the most common cause of Peripheral neuropathy and it ranges from 54% among 1,00,000 people per year. In epidemiological studies from India showed wide prevalence varying from 5 to 2400 per 10,000 population in different community studies.6 Peripheral Neuropathies progress slowly, over more than 5 years. Different clinical neurological scales can be used to assess the severity of Diabetic polyneuropathy. On the basis of NCBI Staging,

NO— No neuropathy

N1a— Signs but no symptoms of neuropathy

N2a— Symptomatic mild diabetic polyneuropathy

N2b— Severe symptomatic diabetic polyneuropathy (as in N2a but patient unable to heel walk)

N3— Disabling diabetic polyneuropathy