Treatment of couples with unexplained subfertility and an unfavourable prognosis: a randomised trial comparing the effectiveness of intrauterine insemination with ovarian hyperstimulation and in-vitro fertilisation with single embryo transfer

Not Applicable

Completed

• Conditions: nexplained Subfertility; Pregnancy and Childbirth; Subfertility

• Registration Number: ISRCTN86744378
• Lead Sponsor: Academic Medical Center (AMC) (The Netherlands)

Brief Summary

2011 results in https://pubmed.ncbi.nlm.nih.gov/21890134/ (added 14/01/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-12-28
• Study Completion: 2008-06-01
• Last Update Posted: 25 January 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 116

Inclusion Criteria

1. Female age between 18 and 36 years
2. Couples must be diagnosed with unexplained subfertility, defined as normal semen (pre-wash total motile sperm count of at least 40 million), spontaneous ovulatory cycle and patent Fallopian tubes, or with mild male subfertility, defined as a post-wash total motile sperm count above three million
3. The couple has poor fertility prospects as calculated by the validated model of Hunault. A poor fertility prospect is defined as a chance of spontaneous pregnancy below 30% within 12 months

Exclusion Criteria

1. Polycystic ovary syndrome
2. Endocrinopathological disease like: Cushing syndrome, adrenal hyperplasia, hyperprolactinemia, acromegaly, imminent ovarian failure, premature ovarian failure, hypothalamic amenorrhea, hypothyroidy, diabetes mellitus type I
3. If not willing or able to sign the consent form

Study & Design

• Study Type: Interventional
• Study Design: Not specified