Comparision the effect of adjuvant Reminfentanil, Dexmedetomidine or metoral with thiopental on hemodynamic status in patients with major depressive disorder candidates for electroconvulsive therapy

Phase 2

Recruiting

• Conditions: major depressive disorder candidates for electroconvulsive therapy.; Mood disorder due to known physiological condition with major depressive-like episode; F06.32

• Registration Number: IRCT20141209020258N178
• Lead Sponsor: Arak University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

All patients with major depressive disorder are candidates for ETC
Consent to participate in the study
18 to 60 years
Body mass index 20 to 30
Patients with major depressive disorder who do not have other psychiatric illnesses at the same time.
No history of underlying heart, lung, kidney and liver diseases
No history of recent CVA or MI
Insensitivity to Remifentanil or Dex Medtomidine or Metoral or Thiopental
All patients who are indicated to receive ECT according to psychiatric treatment criteria.
Absence of pregnancy and breastfeeding

Exclusion Criteria

All patients who experience cardiorespiratory arrest during ECT.
All patients who need intubation after ECT due to prolonged apnea and respiratory failure
All patients who do not experience sufficient and desired seizures during ECT.
All patients who want to withdraw from the study or do not want to continue electroshock therapy.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Average blood pressure. Timepoint: Recovery. Method of measurement: Barometer.;Average heart rate. Timepoint: Recovery. Method of measurement: Pulse oximeter.;Average percentage of oxygen saturation,. Timepoint: Recovery. Method of measurement: Pulse oximeter.;Patient satisfaction. Timepoint: Recovery. Method of measurement: Question.;Agitation. Timepoint: Recovery. Method of measurement: Physical examination.;Seizure duration. Timepoint: Recovery. Method of measurement: Observation.;Recovery period. Timepoint: Recovery. Method of measurement: Observation.