Cannabis Reduction and Functional Outcomes

Not Applicable

Not yet recruiting

• Conditions: Cannabis Use Disorder

• Registration Number: NCT07218471
• Lead Sponsor: Medical University of South Carolina

Brief Summary

This study evaluates the effects of cannabis use reduction among adults diagnosed with cannabis use disorder (CUD). Participants will undergo an 8-week intervention combining motivational interviewing, computerized cognitive behavioral therapy (CBT4CBT), and financial incentives for reduction in urinary cannabinoids. The study aims to assess improvements in cannabis-related problems, sleep, cognitive performance, CUD severity, and quality of life.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-10
• Study First Submitted: 2025-10-13
• Study First Submitted QC: 2025-10-16
• Last Update Submitted: 2025-10-16
• Study First Posted: 2025-10-20
• Last Update Posted: 2025-10-20
• Study Start: 2026-04-01
• Primary Completion: 2029-09-15
• Study Completion: 2030-01-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 176

Inclusion Criteria

• Age 18+
• Urinary cannabinoid level ≥ 50 ng/mL
• DSM-5 diagnosis of CUD (mild, moderate, or severe)
• Willingness to attempt cannabis reduction
• Completion of Intake Visit

Exclusion Criteria

• Serious medical/psychiatric conditions
• Pregnancy or breastfeeding
• Use of cannabis in past 30 days was for medical purposes only
• Discontinuation or reduction of cannabis use may exacerbate a pre-existing condition
• TICS score ≤ 19

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Cannabis-Related Problems	Week 8 (end-of-treatment)	Rutgers Marijuana Problem Index (RMPI)- higher scores associated with worse outcomes.

Secondary Outcome Measures

Name	Time	Method
Total minutes of sleep per night	Week 8 (end-of-treatment)	Measured via Fitbit Charge.
Minutes of light sleep per night	Week 8 (end-of-treatment)	Measured via Fitbit Charge.
Minutes of rapid eye movement (REM) sleep per night	Week 8 (end-of-treatment)	Measured via Fitbit Charge.
Minutes of deep sleep per night	Week 8 (end-of-treatment)	Measured via Fitbit Charge.
Sleep efficiency rating	Week 8 (end-of-treatment)	"Sleep score" as provided by Fitbit Charge. Range is 1-100 with higher scores indicating better sleep quality/efficiency.
Rey Auditory Verbal Learning Test (Verbal Memory) Age-Adjusted Standard Score	Week 8 (end-of-treatment)	NIH Toolbox assessment; Higher scores indicate better cognitive functioning in this domain.
Face/Name Associative Memory Test (Visual Memory) Age-Adjusted Standard Score	Week 8 (end-of-treatment)	NIH Toolbox assessment; Higher scores indicate better cognitive functioning in this domain.
Oral Symbol Digit Test Age-Adjusted Standard Score	Week 8 (end-of-treatment)	NIH Toolbox assessment; Higher scores indicate better cognitive functioning in this domain.
Pattern Comparison Processing Speed Test (Processing Speed) Age-Adjusted Standard Score	Week 8 (end-of-treatment)	NIH Toolbox assessment; Higher scores indicate better cognitive functioning in this domain.