Non-Invasive Brain Stimulation

Not Applicable

• Conditions: Stroke
• Interventions: Device: Transcranial Direct Current Stimulator

• Registration Number: NCT04318522
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

The study focusses on utilizing neuroimaging modalities, including Electroencephalography (EEG) and Functional Magnetic Resonance Imaging (fMRI) to study the impact of non-invasive brain stimulation on the prefrontal cortex during a cognitive task.

Detailed Description

In this study, a total of 40 subjects will be randomly assigned to 2 groups i.e. experimental and sham. Conventional transcranial direct current stimulation (c-tDCS) and high-definition transcranial direct current stimulation (HD-tDCS) will be used to stimulate the prefrontal cortex of the brain. EEG and fMRI will be collected before, during and after stimulation to understand the impact of stimulation on brain dynamics. The investigators hypothesize that the stimulation of the prefrontal cortex will improve performance during cognitive tasks along with changes in the neural processing detected by neuroimaging modalities.

Study Timeline

• Study Start: 2019-06-28
• Status Verified: 2020-03
• Study First Submitted: 2020-03-17
• Study First Submitted QC: 2020-03-21
• Last Update Submitted: 2020-03-21
• Study First Posted: 2020-03-24
• Last Update Posted: 2020-03-24
• Primary Completion: 2020-07
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Right Handedness,
• Age > 18

Exclusion Criteria

• History of any other neurological disease,
• Any psychological or psychiatric disease,
• Significant visual or auditory impairments,
• tDCS contraindications including implanted metallic or electronic devices, seizures or convulsions, and pregnancy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Stimulation Group	Transcranial Direct Current Stimulator	-
Control Group	Transcranial Direct Current Stimulator	-

Primary Outcome Measures

Name	Time	Method
Concentration Rate	1 hour	The percentage of accurate responses during the cognitive task within the stipulated time will be calculated to see an impact on concentration after stimulation
Event related potential latency and amplitude	1 hour	Changes in latency and amplitude of event related potentials including P300 \& N200 would be used as neural marker to understand cognitive processing in the brain.
Reaction Time (RT)	1 hour	Reaction time of the subject during a cognitive task would be a measure to assess changes in performance due to stimulation
Functional Magnetic Resonance Imaging (fMRI)	1 hour	Changes in fMRI connectivity

Trial Locations

Locations (1)

Department of Biomedical Engineering, The Chinese University of Hong Kong; 🇭🇰 Shatin, Hong Kong