Effect of Conventional Transcranial Direct Current Stimulation (c-tDCS) and High-definition Transcranial Direct Current Stimulation (HD-tDCS) on the Prefrontal Cortex
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Reaction Time (RT)
研究概览
简要总结
The study focusses on utilizing neuroimaging modalities, including Electroencephalography (EEG) and Functional Magnetic Resonance Imaging (fMRI) to study the impact of non-invasive brain stimulation on the prefrontal cortex during a cognitive task.
详细描述
In this study, a total of 40 subjects will be randomly assigned to 2 groups i.e. experimental and sham. Conventional transcranial direct current stimulation (c-tDCS) and high-definition transcranial direct current stimulation (HD-tDCS) will be used to stimulate the prefrontal cortex of the brain. EEG and fMRI will be collected before, during and after stimulation to understand the impact of stimulation on brain dynamics. The investigators hypothesize that the stimulation of the prefrontal cortex will improve performance during cognitive tasks along with changes in the neural processing detected by neuroimaging modalities.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Right Handedness,
- •Age > 18
排除标准
- •History of any other neurological disease,
- •Any psychological or psychiatric disease,
- •Significant visual or auditory impairments,
- •tDCS contraindications including implanted metallic or electronic devices, seizures or convulsions, and pregnancy.
研究组 & 干预措施
Stimulation Group
干预措施: Transcranial Direct Current Stimulator (Device)
Control Group
干预措施: Transcranial Direct Current Stimulator (Device)
结局指标
主要结局
Reaction Time (RT)
时间窗: 1 hour
Reaction time of the subject during a cognitive task would be a measure to assess changes in performance due to stimulation
Functional Magnetic Resonance Imaging (fMRI)
时间窗: 1 hour
Changes in fMRI connectivity
Concentration Rate
时间窗: 1 hour
The percentage of accurate responses during the cognitive task within the stipulated time will be calculated to see an impact on concentration after stimulation
Event related potential latency and amplitude
时间窗: 1 hour
Changes in latency and amplitude of event related potentials including P300 \& N200 would be used as neural marker to understand cognitive processing in the brain.
次要结局
未报告次要终点
研究者
Raymond KY Tong
Chairman and Professor
Chinese University of Hong Kong