Accuracy of mRNA EXPRESSION OF SERPIN B3 AND LRG1 IN detecting premalignant lesions of the cervix.

Not Applicable

• Conditions: Health Condition 1: N72- Inflammatory disease of cervix uteri

• Registration Number: CTRI/2020/12/029690
• Lead Sponsor: Manipal College of Health Professions

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

For healthy controls:

1 Negative for intraepithelial lesion

For premalignant lesions:

1 Women above 25 to 65 years attending the department of OBG at Kasturba Hospital, Manipal undergoing Pap smear testing

2 Epithelial cell abnormality ââ?¬â?? Squamous cells which include ASC-US Squamous cells (Atypical squamous cells of uncertain significance), ASC-H (Atypical squamous cells ââ?¬â?? HSIL cannot be excluded), LSIL (Low grade squamous intraepithelial lesion), HSIL (High grade squamous intraepithelial lesion) - Moderate dysplasia (CIN-II), Severe dysplasia (CIN- III)

For malignant lesions:

1 Women with clinically diagnosed carcinoma of cervix attending Radiotherapy and Oncology department.

Exclusion Criteria

For healthy controls:

�NILM without any infection or reactive changes

For premalignant lesions

�Heavy discharge and infections

�Menstruation

�History of CC

�Atypical Glandular cells on Pap test

Study & Design

• Study Type: Observational
• Study Design: Not specified