A clinical trial to study the difference in messenger RNA expression of bone modulators following conventional and accelerated orthodontic treatment
Not Applicable
- Registration Number
- CTRI/2019/04/018742
- Lead Sponsor
- Varsha Salim
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
•Subjects ranging in age from 15 to 25 years and diagnosed with Class I bimaxillary protrusion, Class II camouflage cases, requiring maxillary first premolar extraction as a part of their standard orthodontic care.
Exclusion Criteria
Subjects who are not willing to voluntarily take part in the study.
Subjects with periodontitis.
Subjects with grossly decayed maxillary first premolar.
Subjects with any systemic diseases or syndrome.
Subjects under any medication up to four months before the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The level of mRNA expression of OPG and RANKL following conventional and accelerated orthodontic treatmentTimepoint: The level of mRNA, OPG and RANKL expressions following 14 days after force application.
- Secondary Outcome Measures
Name Time Method Comparison of level of mRNA expression of OPG and RANKL following conventional and accelerated orthodontic treatmentTimepoint: The level of mRNA, OPG and RANKL expressions following 14 days after force application.