Resistance on Antithrombotic Drugs in Ischemic Heart Disease
- Conditions
- Coronary Artery Disease
- Interventions
- Procedure: PCI
- Registration Number
- NCT00742430
- Lead Sponsor
- University of Zagreb
- Brief Summary
The purpose of this study is to determine whether aspirin and clopidogrel resistance measured with Multiplate function analyser has a good correlation with incidence of major adverse cardiac events in patients with coronary artery disease (CAD).
- Detailed Description
Our plan is to enroll 180 patients with diagnosed CAD who electively undergo percutaneous coronary intervention (PCI). Blood samples will be taken just before the procedure and one day after the procedure and analysed on Multiplate function analyser. Assessing aspirin and clopidogrel resistance incidence using Multiplate platelet function analyzer we will also try to find resistance correlation with the incidence of major adverse cardiac events in a one year follow up.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 141
- Elective PCI
- > 7 days on aspirin 100mg therapy before the intervention
- > 7 days on clopidogrel 75mg therapy before the intervention
- Loading dose of clopidogrel
- < 7 days on aspirin therapy before the intervention
- Myocardial infarction less than 30 days before the intervention
- Cerebrovascular incident less that three months before the intervention
- Haemorrhagic diathesis
- Trc < 100
- Htc < 30%
- Creatinine > 140
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Resistant PCI patients who are resistant to standard antithrombotic drugs Nonresistant PCI patients who are not resistant to standard dual antithrombotic drugs
- Primary Outcome Measures
Name Time Method Major adverse coronary event 12 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Clinic of Cardiovascular Diseases, Clinical Medical Centre Rebro
ðŸ‡ðŸ‡·Zagreb, Croatia