Assessment of Aspirin and Clopidogrel Resistance in Ischemic Heart Disease Using Multiplate Function Analyser and it's Correlation With Major Adverse Cardiac Events
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 141
- 试验地点
- 1
- 主要终点
- Major adverse coronary event
研究概览
简要总结
The purpose of this study is to determine whether aspirin and clopidogrel resistance measured with Multiplate function analyser has a good correlation with incidence of major adverse cardiac events in patients with coronary artery disease (CAD).
详细描述
Our plan is to enroll 180 patients with diagnosed CAD who electively undergo percutaneous coronary intervention (PCI). Blood samples will be taken just before the procedure and one day after the procedure and analysed on Multiplate function analyser. Assessing aspirin and clopidogrel resistance incidence using Multiplate platelet function analyzer we will also try to find resistance correlation with the incidence of major adverse cardiac events in a one year follow up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective PCI
- •> 7 days on aspirin 100mg therapy before the intervention
- •> 7 days on clopidogrel 75mg therapy before the intervention
排除标准
- •Loading dose of clopidogrel
- •< 7 days on aspirin therapy before the intervention
- •Myocardial infarction less than 30 days before the intervention
- •Cerebrovascular incident less that three months before the intervention
- •Haemorrhagic diathesis
- •Trc < 100
- •Htc < 30%
- •Creatinine > 140
结局指标
主要结局
Major adverse coronary event
时间窗: 12 months
次要结局
未报告次要终点
研究者
Davor Milicic
prof. dr. sc. F.E.S.C.
University of Zagreb