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Pharmacokinetics, safety and efficacy of methylphenidate during pregnancy in women with Attention-Deficit (Hyperactivity) Disorder

Conditions
Attention deficit hyperactivity disorder
10026906
10009841
Registration Number
NL-OMON49916
Lead Sponsor
Isala Klinieken
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Pending
Sex
Not specified
Target Recruitment
25
Inclusion Criteria

Pregnant with a singleton
Diagnosed with AD(H)D
Age 18 years or older

Exclusion Criteria

Declared unfit by a psychiatrist
Juridical status (care authorization)
Prisoners

Study & Design

Study Type
Observational invasive
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
<p>Serum levels methylphenidate<br /><br>(Immediate release: 2-3 hours after intake,<br /><br>extended release: 7 hours after intake)</p><br>
Secondary Outcome Measures
NameTimeMethod
<p>Secondary outcomes:<br /><br />• Birth weight<br />• Apgar score at 1 and 5 minutes<br />• Score list withdrawal symptoms<br />• Miscarriage<br />• Major congenital malformations<br /><br />Explorative outcome:<br /><br />AD(H)D symptom severity; Weis functional impairment rating scale - self report<br />(WFIRS-S)</p>
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