The effects of magnesium salts on vascular stiffness: a long-term study in healthy overweight and slightly obese men and women.<br>
Completed
- Conditions
- 'Vascular stiffness' en 'Stiffness of the blood vessels'10003216
- Registration Number
- NL-OMON47872
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 162
Inclusion Criteria
- Aged between 45-75 years
- Women postmenopausal: two or more years after last menstruation
- Body mass index between 25-35 kg/m2 (overweight and slightly obese)
Exclusion Criteria
- High habitual dietary magnesium intake
- Plasma glucose * 7.0 mmol/L
- Serum total cholesterol * 8.0 mmol/L
- Serum triacylglycerol * 4.5 mmol/L
- Current smoker, or smoking cessation <12 months
- Diabetic patients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Vascular stiffness</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Blood pressure<br /><br>- Gut microbiote<br /><br>- Urine, plasma and intracellular magnesium<br /><br><br /><br>Markers of:<br /><br>- Vascular function<br /><br>- Inflammation<br /><br>- Vascular activity</p><br>