Combination of Mixed Drugs vs Ibuprofen: a Randomized Clinical Trial

Not Applicable

Completed

• Conditions: Swelling Lips &Amp; Face; Trismus; Pain

• Registration Number: NCT07133360
• Lead Sponsor: Universidad Complutense de Madrid

Brief Summary

Combination of vitamins and melatonine compared with the conventional use of ibuprofen after surgical third molar extraction

Detailed Description

Not available

Study Timeline

• Study Start: 2025-02-01
• Primary Completion: 2025-04-01
• Study Completion: 2025-05-01
• Study First Submitted: 2025-06-20
• Status Verified: 2025-08
• Study First Submitted QC: 2025-08-13
• Last Update Submitted: 2025-08-13
• Study First Posted: 2025-08-21
• Last Update Posted: 2025-08-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Healthy volunteers, non ibuprofen allergic, presence of impacted lower third molar

Exclusion Criteria

• Diseases that avoid surgical intervention

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Trismus	7 DAYS	Opening limitation
Post operative pain	10 DAYS	VAS pain scale
Swelling	7 DAYS	Face measurement for swelling

Secondary Outcome Measures

Name	Time	Method
Rescue analgesia	7 DAYS	Need for more medications
Inflammatory profile	7 days	Blood cytokines

Trial Locations

Locations (1)

Complutense University of Madrid; 🇪🇸 Madrid, Spain