A comparative study of melatonin and gabapentin in reducing preoperative anxiety
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Difference in the change in VAS anxiety score
研究概览
简要总结
Reductionin preoperative anxiety reduces postoperative pain, improves post surgeryrecovery and even leads to early discharge. In addition providing analgesiabefore the start of surgery(Preemptive analgesia) has been also been associatedwith reduced postoperative pain. Patients suffering from trauma have highstress levels making them it even more pertinent to tackle preoperative anxietyand pain. Through this project we intend to find the appropriate premedicationwhich reduces preoperative anxiety and thereby reduces postoperative pain andthus improves patient outcome.
ExpectedOutcome**:** It isexpected that melatonin will be superior to alprazolam and gabapentin inreducing preoperative anxiety as well as postoperative analgesic requirements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Permuted block randomization, fixed
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •PAtients undergoing routine surgery after trauma ASA I and asa II patients.
排除标准
- •a)Patients for emergency surgeries b)Surgeries taking place after 1pm (to account for diurnal variation in cortisol levels) c)Patients having altered mental state, history of psychiatric disorder, history of drug abuse or those on chronic pain medication.
结局指标
主要结局
Difference in the change in VAS anxiety score
时间窗: Difference in the change in VAS anxiety score at 90 minutes after drug administration
次要结局
- Change in IL6 and serum cortisol levels(90 minutes post drug administration)