Quality of Life Change in Patients Undergoing Parathyroidectomy With End-stage Renal Failure

Not yet recruiting

• Conditions: End Stage Renal Failure; Secondary Hyperparathyroidism
• Interventions: Other: Quality of life progression after parathyroidectomy

• Registration Number: NCT06378931
• Lead Sponsor: Chunling Jiang

Brief Summary

The purpose of this study is to characterize the quality of life change in patients undergoing parathyroidectomy with secondary hyperparathyroidism due to end-stage renal failure.

Detailed Description

Study participants will be asked questions about age, gender, education level, clinical symptoms, intensities of depression and anxiety, etc, and they will also be questioned regarding the prior quality of life score, as measured by the health-related quality of life 36-item Short-Form (SF-36) survey before surgery. Then, study participants will be contacted at one, three, six months, and 1 year after surgery, and asked questions about their SF-36 score, depression, and anxiety intensity.

Study Timeline

• Status Verified: 2024-03
• Study First Submitted: 2024-03-26
• Study Start: 2024-04-15
• Study First Submitted QC: 2024-04-21
• Last Update Submitted: 2024-04-21
• Study First Posted: 2024-04-23
• Last Update Posted: 2024-04-23
• Primary Completion: 2025-12-30
• Study Completion: 2025-12-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Age: ≥18 years old;
• Patients scheduled for parathyroidectomy with secondary hyperparathyroidism due to end-stage renal failure

Exclusion Criteria

• Patients refuse to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Quality of life change in patients Undergoing Parathyroidectomy with end-stage renal failure	Quality of life progression after parathyroidectomy	Quality of Life Progression in Patients Undergoing Parathyroidectomy With Secondary Hyperparathyroidism Due to End-stage Renal Failure

Primary Outcome Measures

Name	Time	Method
Measure quality of life scores change with respect to time	up to 1 year	Quality of life will be assessed by the 36-Item short form health survey scale, Subjects complete one response from a range of options for each of the 36 questions. A combination of item response is then aggregated to calculate a score for each of the eight dimensions listed. The scores for each dimension range from 0 to 100, with higher scores indicating better health status

Secondary Outcome Measures

Name	Time	Method
Length of hospital stay	through study completion, an average of 1 week	Determined by the number of days from admittance to discharge
Measure bone pain scores change with respect to time	up to 1 year	The bone pain is evaluated using numerical rating scale (NRS). NRS scores range from 0 to 10 points, with 0 points representing no pain, 1-3 points representing mild pain, 4-6 points representing moderate pain, 7-9 points representing severe pain and 10 points representing the strongest pain.
Measure anxiety and depression score change with respect to time	up to 1 year	The anxiety and depression were evaluated using Hospital anxiety and depression Scale (HADS). The HADS consists of 14 questions, with 7 items each for the anxiety and depression subscales. The score for each item ranges from 0 to 3 points, and scores are summed to yield a separate score for anxiety (HADS-A) and depression (HADS-D).