Evaluation of Neopterin Levels in Pre and Post-menopausal Women With Periodontitis Following Non Surgical Therapy

• Conditions: Periodontitis
• Interventions: Procedure: Non surgical periodontal therapy

• Registration Number: NCT02357745
• Lead Sponsor: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Brief Summary

Neopterin has been identified as a marker of cellular immune system activation. It is synthesized by macrophages upon stimulation with the cytokine interferon-gamma and is indicative of a pro-inflammatory immune status. Neopterin concentration increases with increasing severity of periodontal disease in diverse body fluids like Urine, Saliva and Plasma. Hence Neopterin can be considered as an important inflammatory marker in periodontal disease as well as other systemic diseases.

Detailed Description

At baseline - plasma, urine and saliva samples were collected and analysed for neopterin levels from the pre and post-menopausal women with periodontitis . Followed by scaling and root planing done in both the groups. After 3 months again these 3 samples were collected and analysed for post treatment neopterin levels

Study Timeline

• Status Verified: 2015-01
• Study First Submitted: 2015-01-21
• Study Start: 2015-02
• Study First Submitted QC: 2015-02-05
• Last Update Submitted: 2015-02-05
• Study First Posted: 2015-02-06
• Last Update Posted: 2015-02-06
• Primary Completion: 2015-05
• Study Completion: 2015-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

• moderate to chronic periodontitis
• non-smokers
• minimum 15 natural teeth present

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Exclusion Criteria

• patients on long term steroid medication
• with gross oral pathology or tumors
• undergoing hormone replacement therapy
• not undergone periodontal therapy in past 6 months
• under medication in past 6 months
• systemic disorders and drugs which influence the periodontium

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pre-menopausal with periodontitis	Non surgical periodontal therapy	non surgical periodontal therapy ( scaling and root planing)
Post-menopausal with periodontitis	Non surgical periodontal therapy	non surgical periodontal therapy ( scaling and root planing)

Primary Outcome Measures

Name	Time	Method
Co-relating neopterin and periodontitis levels in pre and post menopausal women	3 months