Biochemical Evaluation of Plasma,Urine and Salivary Neopterin Levels in Pre and Post-menopausal Women With Periodontitis Following Non-surgical Therapy
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- Co-relating neopterin and periodontitis levels in pre and post menopausal women
研究概览
简要总结
Neopterin has been identified as a marker of cellular immune system activation. It is synthesized by macrophages upon stimulation with the cytokine interferon-gamma and is indicative of a pro-inflammatory immune status. Neopterin concentration increases with increasing severity of periodontal disease in diverse body fluids like Urine, Saliva and Plasma. Hence Neopterin can be considered as an important inflammatory marker in periodontal disease as well as other systemic diseases.
详细描述
At baseline - plasma, urine and saliva samples were collected and analysed for neopterin levels from the pre and post-menopausal women with periodontitis . Followed by scaling and root planing done in both the groups. After 3 months again these 3 samples were collected and analysed for post treatment neopterin levels
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •moderate to chronic periodontitis
- •non-smokers
- •minimum 15 natural teeth present
排除标准
- •patients on long term steroid medication
- •with gross oral pathology or tumors
- •undergoing hormone replacement therapy
- •not undergone periodontal therapy in past 6 months
- •under medication in past 6 months
- •systemic disorders and drugs which influence the periodontium
结局指标
主要结局
Co-relating neopterin and periodontitis levels in pre and post menopausal women
时间窗: 3 months
次要结局
未报告次要终点
研究者
DR.CH.SUMADHURA
SUMADHURA
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre