Pioglitazone in Patients with Recurrent/ Refractory Inoperable High-Grade Osteosarcoma
Not Applicable
- Conditions
- Health Condition 1: C408- Malignant neoplasm of overlappingsites of bone and articular cartilage of limb
- Registration Number
- CTRI/2021/09/036956
- Lead Sponsor
- Cancer Institute WIA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients with inoperable recurrent/refractory high-grade osteosarcoma who fail first-line chemotherapy
2. Patients must have normal cardiac function (as assessed by ECG and 2D Echocardiogram)
3. ECOG Performance status 0-3
4. Patients must have normal organ function as defined below:
a) total bilirubin <1.5 X institutional upper limit of normal
b) AST(SGOT)/ALT(SGPT) <2.5 X institutional upper limit of normal
Exclusion Criteria
1. Uncontrolled hypertension
2. History of diabetes mellitus
3. Pregnant and lactating women
4. Past history of ischemic heart disease or cardiac failure
5. Symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method