The dynamic effects of hypertension on the brain and its vessels
- Conditions
- HypertensionHigh bloodpressure1000796310057166
- Registration Number
- NL-OMON45503
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion criteria for patients with hypertension:
• 18 years and older
• Hypertension >140/90 mm Hg at inclusion.
• Patients must be part of the *zorgpad hypertensie*. These patients are temporary drug naïve and are switched on to medication after two weeks of being drug naïve as part of this *zorgpad hypertensie*.;Inclusion criteria for healthy volunteers:
• 18 years and older
Exclusion criteria for patients with hypertension:
• Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body)
• Pregnancy
• Non-Dutch speaking
• Illiterate;Exclusion criteria for healthy volunteers:
• Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body)
• Pregnancy
• Treated with antihypertensive medication
• Non-Dutch speaking
• illiterate
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are the structural and functional MRI differences<br /><br>between baseline and follow-up scans (both 3T and 7T MRI).</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameters are the structural and functional MRI<br /><br>differences between patients and healthy volunteers.<br /><br><br /><br>The tertiary study parameters are the difference between morning and evening<br /><br>total brain volumes, CSF volumes, and perfusion status as measured with 3T MRI.<br /><br><br /><br>The quaternary study parameter/endpoint is the clinical consequences of<br /><br>hypertension as measured with neuropsychological tests. </p><br>