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Clinical Trials/NL-OMON35291
NL-OMON35291
Recruiting
Not Applicable

Induced hypertension for delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage: a feasibility study - Induced hypertension for DCI after SAH

niversitair Medisch Centrum Utrecht0 sites24 target enrollmentTBD
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Conditionsintra-cerebral haemorrhagebrain haemorrhage10007963

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
intra-cerebral haemorrhage
Sponsor
niversitair Medisch Centrum Utrecht
Enrollment
24
Status
Recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Interventional

Investigators

Sponsor
niversitair Medisch Centrum Utrecht

Eligibility Criteria

Inclusion Criteria

  • •1\. Admission to the hospital
  • •2\. Age 18 years or over
  • •3\. Aneurysmal SAH, demonstrated on CT\-angiography or cerebral agiograph, with onset less than 72 hours before admission
  • •4\. Glascow Coma Sum Score above 8\.
  • •5\. DCI (decrease of 2 GSC points or all new neurological focal deficits), diagnosed by a neurologist, neurosurgeon or intensivist within 3 hours after deterioration.
  • •6\. Informed consent

Exclusion Criteria

  • •1\. Symptomatic cerebral aneurysm not yet treated by coiling or clipping
  • •2\. Co\-existing severe head injury.
  • •3\. A history of a cardiac rhythm disorder, necessitating medical treatment.
  • •4\. A history of a left ventricular pump failure, necessitating medical treatment.
  • •5\. Pregnancy.
  • •6\. Known allergy for CT\-contrast agents.
  • •7\. Renal failure, defined as a serum creatinine \> 150 µmol/l
  • •8\. Other causes cause for neurological deterioration (see page 15 of the study protocol for the differential diagnosis)
  • •9\. Severe hypertension, defined as a MAP of 120 mmHg or higher

Outcomes

Primary Outcomes

Not specified

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