Induced hypertension for treatment of delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage. - Induced hypertension for DCI after SAH.

Academisch Medisch Centrum0 sites240 target enrollmentTBD

Conditionsbrain haemorrhage intracerebral haemorrhage 10007963

Overview

Phase: Phase 3
Intervention: Not specified
Conditions: brain haemorrhage
Sponsor: Academisch Medisch Centrum
Enrollment: 240
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

No summary available.

Registry

who.int

Start Date

TBD

End Date

TBD

Last Updated

last year

Study Type

Interventional

Investigators

Sponsor

Academisch Medisch Centrum

Eligibility Criteria

Inclusion Criteria

•1\. Admission to the hospital 2\. Age 18 years or over 3\. Aneurysmal SAH, demonstrated on CT\-angiography or cerebral angiograph 4\. DCI (decrease of at least one point on the GSC sumscore, unless the decrease doesn\*t reflect DCI as evaluated by the treating physician, and/or all new neurological focal deficits), diagnosed by a neurologist, neurosurgeon or intensivist, 5\. Informed consent

Exclusion Criteria

•0\. Evidence of DCI after the SAH at time of asking for informed consent, unless symptoms of DCI started within 3 hours 1\. Co\-existing severe head injury. 2\. A perimesencephalic haemorrhage. 3\. A history of a ventricular cardiac rhythm disorder, necessitating medical treatment. 4\. A history of left ventricular heart failure, necessitating medical treatment. 5\. Pregnancy. 6\. Transferral to another hospital, 7\. moribund, 8\. Other cause for neurological deterioration (see page 19 of the study protocol for the differential diagnosis) 9\. Symptomatic cerebral aneurysm not yet treated by coiling or clipping, 10\. Severe hypertension, defined as a spontaneous MAP of 120 mmHg or more at the moment of evaluation for trial participation, 11\. Any contraindication for induced hypertension (such as a cardiac complication necessitating medical treatment) as evaluated by the treating physician. And furthermore, in selected centres where the sub study with CT perfusion will be performed: 12\. known allergy for CT\-contrast agents. 13\. renal failure, defined as a serum creatinine \> 150 µmol/l, because of the risk of contrast nephropathy. 14\. diabetes mellitus.

Outcomes

Primary Outcomes

Not specified

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