THE TREATMENT OF HYPERTENSION ASSOCIATED WITH SEVERE PREECLAMPSIA.A RANDOMIZED CONTROLLED TRIAL OF URAPIDIL VERSUS NICARDIPINE.The URANIC trial. - URANIC

Hôpitaux Universitaires de Strasbourg0 sites366 target enrollmentJune 26, 2015

Overview

No summary available.

Registry

who.int

Start Date

June 26, 2015

End Date

TBD

Last Updated

5 years ago

Study Type

Interventional clinical trial of medicinal product

Sex

Female

Sponsor

Hôpitaux Universitaires de Strasbourg

•Adult patients
•Singleton pregnancy
•Patients with remaining hypertension despite an oral treatment for who an iv antihypertensive treatment is indicated
•Patient with PE, as defined by :
•Systolic Blood Pressure (BP) \= 140 mmHg and/or Diastolic BP \= 90 mmHg, after the 20th week of amenorrhea, without chronic hypertension,
•Proteinuria \> 300 mg.day\-1 or \> 2 crosses(\+\+) on an urinary dipstick,
•Patient with severe PIH, as defined by :
•Systolic BP \= 160mmHg and/or Diastolic BP \=110mmHg, after the 20th week of amenorrhea, without chronic hypertension,
•Written informed consent signed and dated by both investigator and patient
•Are the trial subjects under 18? no

•Known allergy to the study drugs
•Contra\-indication to the study drugs :stenosis of the aortic isthmus, arteriovenous shunt, coarctation of the aorta, unstable angina, compensatory hypertension, myocardial infarction \< 8 days.
•Person with difficulty understanding information
•Person with diminished responsiblity,
•Ongoing intravenous antihypertensive treatment,
•No pressure cuff adapted to the morphology of the arms of the patients
•Concomitant use of 5 phosphodiesterase inhibitors
•Participation in a clinical trial within 6 months prior to inclusion