Examination of the relevance of plant products on vitamin B12-supply of vegetarians and vegans
- Conditions
- VITAMIN B12 MALNUTRITIO
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 73
Non-smokers; vegetarian and / or vegan diet for at least 1 years; serum cobalamin range between 110-310 pmol/l; written consent after information about study contents and study procedure; Ability and willingness of study participants to follow study leaders instructions
Intake of vitamin B12-containing dietary supplements 3 month before study begin; severe chronic illness (Cancer, diabetes mellitus Typ I, manifest coronary heart disease), severe kidney or liver diseases; Allergies or intolerances regarding study product contents; chronic gastroinestinal diseases (especially small intestine e.g. duodenal ulcer, liver, pancreas) and state after gastrointestinal surgical procedure e.g. nontropical sprue, short bowel syndrome); Heart or gastrointestinal surgery; immediate planned surgery; BMI >30 kg/m²; addiction to alcohol and/or drugs; smoking; Pregnancy and lactation; missing consent or refusing / reset of the consent
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in holotranscobalamin (week 8 (t8) in comparison to week 4 (t4); week 8 (t8) in comparison to baseline (t0); week 4 (t4) in comparison to baseline (t0)) (blood parameter)<br><br><br>
- Secondary Outcome Measures
Name Time Method Changes in serum cobalamin (week 8 (t8) in comparison to week 4 (t4); week 8 (t8) in comparison to baseline (t0); week 4 (t4) in comparison to baseline (t0)) (blood parameter); <br><br>Changes in methylmalonic acid (week 8 (t8) in comparison to week 4 (t4); week 8 (t8) in comparison to baseline (t0); week 4 (t4) in comparison to baseline (t0)) (blood parameter); <br><br>Changes in folic acid (week 8 (t8) in comparison to week 4 (t4); week 8 (t8) in comparison to baseline (t0); week 4 (t4) in comparison to baseline (t0)) (blood parameter)<br>