Remote Evaluation of MIND Diet
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- University of Illinois at Urbana-Champaign
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Processing Speed
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in persons with Multiple Sclerosis (MS). The main question it aims to answer is:
Does the MIND diet improve cognitive performance relative to a control diet in persons with MS?
Participants will:
Consume one meal that follows the MIND diet or a control meal every day for 3 months, complete online surveys and cognitive testing before and after, and keep a record of the food they eat during the study.
Detailed Description
The purpose of this study is to understand how a healthy diet is related to thinking ability and memory in people with multiple sclerosis (MS). This study is fully remote consisting of meals being delivered to participant homes using Daily Harvest meal delivery service. Participants will be asked to consume a microwaveable study meal or prepackaged smoothie every day for 12 weeks. The study meals and smoothies will follow either a dietary pattern thought to improve brain health (Mediterranean-DASH Intervention for Neurodegenerative Delay; MIND), or a control diet, and will include foods commonly found in grocery stores. Participants will not know which diet they are assigned to (active or control). Participants will also be asked to follow simple dietary guidance on a healthy diet in addition to the meals provided. Participants will complete a series of online forms or surveys. Additionally, participants will complete an online cognitive battery from Cambridge Neuropsychological Test Automated Battery (CANTAB) at the beginning and end of the study.
Investigators
Naiman Khan
Associate Professor
University of Illinois at Urbana-Champaign
Eligibility Criteria
Inclusion Criteria
- •Individuals aged 18-64 years old
- •Self-reported diagnosis of Multiple sclerosis (MS)
- •20/20 or corrected vision
- •No other neurodegenerative disease diagnosis
- •Stable disease-modifying therapy (DMT) within 6 months
- •Not Pregnant or lactating
- •No food allergies or intolerances
- •Able to consume study meals
- •Not enrolled in another dietary, exercise, or medication study during the study
- •Access to a computer/laptop with internet
Exclusion Criteria
- •Individuals younger than 18 or older than 64 years old
- •No self-reported diagnosis of Multiple sclerosis (MS)
- •Not 20/20 or uncorrected vision
- •Other neurodegenerative disease diagnosis
- •Disease modifying therapy (DMT) less than 6 months
- •Pregnant or lactating
- •Food allergies or intolerances
- •Not able to consume study meals
- •Enrolled in another dietary, exercise, or medication study during the study
- •No access to a computer/laptop with internet
Outcomes
Primary Outcomes
Processing Speed
Time Frame: 12 weeks (Baseline vs. Follow Up)
Digit Span from CANTAB online battery
Visual Processing
Time Frame: 12 weeks (Baseline vs. Follow Up)
Match to Sample Visual Search from CANTAB online battery
MIND Scores
Time Frame: 12 weeks (Baseline vs. Follow Up)
MIND dietary pattern scores calculated from diet records/surveys. Validated score to determine how someone adheres to the dietary pattern, scale of 0 to 14 with a higher score indicating greater adherence to the pattern.
Information Processing
Time Frame: 12 weeks (Baseline vs. Follow Up)
Rapid Visual Information Processing Task from CANTAB online battery
Memory
Time Frame: 12 weeks (Baseline vs. Follow Up)
Spatial Working Memory from CANTAB online battery
Learning
Time Frame: 12 weeks (Baseline vs. Follow Up)
Paired Associates Learning Task from CANTAB online battery
Secondary Outcomes
- Refusal Rates(Throughout the recruitment process.)
- Attrition rates(Throughout the intervention (weeks 1-12))
- Retention rates(Throughout the intervention (weeks 1-12))
- Adherence/Compliance Rates(Throughout the intervention (weeks 1-12))
- Recruitment Rates(Throughout the recruitment process)
- Participant Experience and Burden(Throughout the intervention (weeks 1-12))