Giant Cell Tumor of the Extremities Treated With Surgery and/or Medical Treatment

Completed

• Conditions: Giant Cell Tumor of Bone

• Registration Number: NCT02996734
• Lead Sponsor: Istituto Ortopedico Rizzoli

Brief Summary

The purpose of this project is to present the outcomes of patients with giant cell tumor of bone (GCTB) who were treated with surgery and/or medical treatment in a single institution.

Detailed Description

The investigators retrospectively review patients treated for GCTB of the extremities between 1990 and 2013 in a single institution. We evaluate the recurrence free survival rate after surgical and medical treatment of patients with GCTB of the extremities to determine the influence of the surgical approach, denosumab therapy, local tumor presentation, and demographic factors on the risk of recurrence.

Study Timeline

• Study Start: 2016-04
• Status Verified: 2016-12
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Study First Submitted: 2016-12-15
• Study First Submitted QC: 2016-12-16
• Study First Posted: 2016-12-19
• Last Update Submitted: 2016-12-21
• Last Update Posted: 2016-12-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 412

Inclusion Criteria

• giant cell tumors of the extremities

Exclusion Criteria

• giant cell tumors of the spine and pelvis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
local recurrence rate after surgical and medical treatment	within the first 36 months after surgery