MRI-guided single dose preoperative radiotherapy in low-risk breast cancer
Phase 2
Withdrawn
- Conditions
- 10006291Breast cancermammary neoplasm
- Registration Number
- NL-OMON46628
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 70
Inclusion Criteria
Female, ><= 50years, breast cancer, ER positive tumor, Her2 negative tumor, tumor maximum 3cm in diameter, BR grade 1 or 2
Exclusion Criteria
Indication for chemotherapy, lobular carcinoma, previous breast cancer, lymph node or distant metastasis, BRCA1, BRCA2 or CHEK2 gene mutation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Pathologic complete response.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Radiologic response, relation between radiologic response and pathologic<br /><br>response, relation between pathology of biopsy and surgical specimen, toxicity,<br /><br>relation between immunoresponse and pathologic response, relation between<br /><br>circulation tumor DNA and pathologic response, cosmetic result, quality of<br /><br>life, workability or frailty (depending on age), disease free survival, overall<br /><br>survival.</p><br>