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临床试验/NL-OMON28692
NL-OMON28692已完成不适用

Does antenatal allopurinol during asphyxia reduce post-hypoxic-ischemic reperfusion damage in the newborn?

Prof dr. F. van Bel0 个研究点目标入组 220 人开始时间: 待定最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
220

研究概览

简要总结

Van Bel F, Shadid M, Moison RM, Dorrepaal CA, Fontijn J, Monteiro L, Van De Bor M, Berger HM. Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity. Pediatrics. 1998 Feb;101(2):185-93.

Shadid M, Moison R, Steendijk P, Hiltermann L, Berger HM, van Bel F. The effect of antioxidative combination therapy on post hypoxic-ischemic perfusion, metabolism, and electrical activity of the newborn brain. Pediatr Res. 1998 Jul;44(1):119-24.

Benders MJ, Bos AF, RademakerCM etal. Early postnatal allurinol does not improve short term outcome after severe birth asphyxia. Arch Dis Child Fetal neonatal Ed 2006:91:163-165

Kaandorp JJ, Benders MJ, Rademaker CM, Torrance HL, Oudijk MA, de Haan TR, Bloemenkamp KW, Rijken M, van Pampus MG, Bos AF, Porath MM, Oetomo SB, Willekes C, Gavilanes AW, Wouters MG, van Elburg RM, Huisjes AJ, Bakker SC, van Meir CA, von Lindern J, Boon J, de Boer IP, Rijnders RJ, Jacobs CJ, Uiterwaal CS, Mol BW, Visser GH, van Bel F, Derks JB. Antenatal allopurinol for reduction of birth asphyxia induced brain damage (ALLO-Trial); a randomized double blind placebo controlled multicenter study. BMC Pregnancy and Childbirth 2010;10:8.

Kaandorp JJ, van Bel F, Veen S, Derks JB, Groenendaal F, Rijken M, Roze E, Uniken Venema MMA, Rademaker CMA, Bos AF and Benders MJNL. Long-term neuroprotective effects of allopurinol after moderate perinatal asphyxia. Follow-up of two randomised controlled trials. Arch Dis Child Fetal Neonatal Ed. 2011 Nov 17.

研究设计

研究类型
Interventional

入排标准

入选标准

  • 1. Gestational age of 36 weeks or more, determined by maternal dates and/or Ballard score.
  • 2. Objective fetal hypoxia registered by:

排除标准

  • 1. Congenital, chromosomal or syndromal malformations.

研究者

发起方
Prof dr. F. van Bel

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