Effect of Opioid-free Anesthesia on Perioperative Period After Video-assisted Thoracoscopic Lobectomy: a Retrospective Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Thoracic
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Cumulative dose of postoperative opioid
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No study has been conducted to demonstrate the feasibility and safety of an Opioid-Free Anesthesia (OFA) protocol compared to Opioid-Based Anesthesia (OBA) in thoracic surgery, at risk for intense post-operative pain, to improve patient care. The aim of the present study was to evaluate the effect of OFA on post-operative opioids consumption, pain and the post-operative period after lobectomy by Video-Assisted Thoracoscopy Surgery (VATS). systems.
Investigators perform a retrospective, single-center study in 2019. Patients were divided into two groups: OFA (with dexmedetomidine) or OBA (sufentanyl).
Investigators analyse the total postoperative opioid consumption in the 48 h after surgery. Investigators asses pain intensity in the 48 h after surgery, operative hemodynamic stability, Post-Operative Pain (POP) in Post-Anesthesia Care Unit (PACU) and POP on day 30.
All data are available in the medical record
Hypothesis: OFA can reduce post-operative opioids consumption, pain in lobectomy by video-assisted thoracoscopy surgery (VATS).
Investigators
Eligibility Criteria
Inclusion Criteria
- •All consecutive patients admitted for lobectomy or wedge video-assisted thoracoscopy
- •Opioid Free Anesthesia (OFA) administration was left to the discretion of the attending anesthetist according to his or her practices and habits.
- •age 18 or over
- •lobectomy or wedge resection by Video-Assisted Thoracoscopy Surgery (VATS)
Exclusion Criteria
- •toxicomania,
- •epidural analgesia use,
- •thoracotomy conversion
- •Patient-Controlled Analgesia with morphine (PCA)
- •Patient who object to take part of the study.
Outcomes
Primary Outcomes
Cumulative dose of postoperative opioid
Time Frame: 48 hours
The primary endpoint was the cumulative dose of postoperative opioid in the first 48 h (D2) (in milligrams of oral morphine equivalent) which included morphine and tramadol after conversion (1mg of intra-veinous morphine = 3 mg of oral morphine, and 10 mg of oral morphine = 50 mg of oral tramadol)