Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery
- Conditions
- Opioid UsePostoperative Nausea and VomitingThoracic Diseases
- Registration Number
- NCT05411159
- Lead Sponsor
- Beijing Chao Yang Hospital
- Brief Summary
This study aimed to verify whether an Opioid-free Anesthesia (OFA) could effectively reduce the incidence of PONV after thoracoscopic-assisted surgery compared with standard general anesthesia (OA) regimens.
- Detailed Description
Postoperative Nausea and Vomiting (PONV) is one of the most common complications after general anesthesia, which significantly reduces postoperative comfort and satisfaction of patients perioperatively. Meta-analysis showed that Opioid-free Anesthesia (OFA) significantly reduced the risk of postoperative PONV events in patients undergoing gynecology, breast, and abdominal surgery compared with standard general anesthesia (OA). The main hypothesis of the study is that an OFA could reduce the incidence of PONV in patients after thoracoscopic-assisted surgery than OA.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 168
- Inpatients planning elective thoracoscopic lobectomy or wedge resection under general anesthesia
- ASA classification > 4
- BMI>35kg/m2
- Unable to communicate before surgery
- Received radiation therapy, chemotherapy, opioids or hormonal drugs within 14 days before surgery
- Anticipated intolerance to the anesthesia protocol of this study
- Expect prolonged mechanical ventilation after surgery
- Decline
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Incidence of postoperative nausea and vomiting 24 hours after surgery Assessed using Myles's simplified postoperative nausea and vomiting impact scale.
The scale on the scale is a composite of the following 2 parts:
(1) vomited or had dry-retching (0-3 points), and (2) nausea ( 0-3 points). (High scores represent severe).
The score\>0 is regarded as PONV occurred.
- Secondary Outcome Measures
Name Time Method The score of Simplified postoperative nausea and vomiting impact scale 24 hours after surgery Assessed using Myles's simplified postoperative nausea and vomiting impact scale.
The score on the scale is a composite of the following 2 parts:
(1) vomited or had dry-retching score (0-3 points), and (2) nausea ( 0-3 points). (High scores represent severe)Quality of post-operative recovery 24 hours after surgery Assessed by the of quality of recovery-15 (QoR-15) scale. (0-150 points, High scores represent better)
Postoperative pain at rest and cough 24 hours after surgery Assessed by the Numerical Assessment Scale (NRS) for pain. (0-10 points, High scores represent worse)
The six minute walking test (6MWT) 48 hours after surgery Assessed by the 6MWT worksheet and report. (High scores represent better)
Related Research Topics
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Trial Locations
- Locations (1)
Beijing Chaoyang Hospital
🇨🇳Beijing, Beijing, China
Beijing Chaoyang Hospital🇨🇳Beijing, Beijing, China