Transcutaneous pO2, Transcutaneous pCO2 and Central Venous SO2 Variations to Define Fluid Responsiveness
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Fluid Responsiveness
研究概览
简要总结
Fluid challenge is often carried out in critical ill patients. Its responsiveness usually requires invasive monitoring. To use non-invasive methods is very tempting. Investigators hypothesize that transcutaneous pO2,transcutaneous pCO2 and Central Venous SO2 variations provide feasible estimation on fluid responsiveness in critical ill patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years and older ICU patients;
- •Septic shock;
- •Monitored with PICCO or Swan-Ganz catheter;
- •The decision of fluid challenge made by the treating physician;
排除标准
- •Evidence of fluid overload;
- •Pregnancy
研究组 & 干预措施
Septic shock
Adult patients (at least 18 years of age) with refractory hypotension secondary to sepsis who, at the discretion of treating physicians, required fluid challenge in the presence of invasive hemodynamic monitoring. Refractory hypotension was defined as need of vasopressors to maintain systolic blood pressure (SBP) no less than 90 mmHg despite adequate fluid resuscitation.
干预措施: fluid challenge (Other)
结局指标
主要结局
Fluid Responsiveness
时间窗: Immediately after fluid challenge, average 5 minutes
Increase in cardiac index ≥ 10% after fluid challenge
次要结局
未报告次要终点
研究者
Bin Du
Director of Medical ICU
Peking Union Medical College Hospital