Diagnostic and Prognostic Blood Markers in Non Specific Low Back Pain
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- IL 6
研究概览
简要总结
• To compare the diagnostic and prognostic blood markers in acute and chronic nonspecific low back pain with healthy controls
详细描述
- To compare the diagnostic and prognostic blood markers in acute and chronic nonspecific low back pain with healthy controls
- To predict the diagnostic and prognostic blood markers on sleep, depression and anxiety in acute and chronic non specific low back pain.
- To compare the effect of physical activity with blood markers in acute and chronic non specific low back pain.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Both male & Female patients
- •Age group 18-60 Years
- •Diagnosed with nonspecific low back pain in acute/flared stage
排除标准
- •Any serious conditions like neurological conditions
- •Any infection
- •Spinal Surgery
- •Cognitive Impairments
- •Refusal to sign consent
- •patients taking any type of psychological management or rheumatologic disease would be excluded
结局指标
主要结局
IL 6
时间窗: 24 weeks
Interleukin-6 promptly and transiently produced in response to infections and tissues injuries.
IL 1
时间窗: 24 weeks
Interleukin-1 is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory response to infections
CRP
时间窗: 24th weeks
It measures the level of C-reactive proteins in a sample of blood. CRP is a protein made by lever. It shows inflammation in the body
IL-1 BETA
时间窗: 24 weeks
IL-1Beta is a pro inflammatory cytokine implicated in pain, inflammation and autoimmune condition
Fibrinogen
时间窗: 24 weeks
Fibrinogen is a protein produced by liver, its high levels may occur as a part of normal response to infection or inflammation.
TNF ALPHA
时间窗: 24 weeks
TNF ALPHA is an adipokine and a cytokine. It is one of the most important pro-inflammatory cytokine.
IL-8
时间窗: 24 weeks
Interleukin-8 is a chemoattractant cytokine produced by variety of tissues and blood cells. It activates neutrophils in inflammatory regions
次要结局
- Örebro Musculoskeletal Pain Screening Questionnaire (ÖMPSQ)(24 weeks)
- Numeric rating scale(24 weeks)
- Low Back outcome scale(24 weeks)
- International Physical Activity Questionnaire(24 weeks)
- Chronic Pain Grade Scale(24 weeks)
- Hospital Anxiety and Depression Scale(24 weeks)
- Pain Self-Efficacy Questionnaire (PSEQ)(24 weeks)
- Roland-Morris Disability Questionnaire(24 weeks)
- Coping Strategies Questionnaire(24 weeks)
- Center for Epidemiological Studies-Depression Scale (CES-D):(24 weeks)
- Pain catastrophizing scale(24 weeks)
- Job Content Questionnaire(24 weeks)
- Pittsburgh Sleep Quality Index (PSQI)(24 week)
- Tampa Scale of Kinesiophobia (TSK)(24 weeks)
- Fear-Avoidance Beliefs Questionnaire (FABQ)(24 weeks)
- Keele STarT Back Screening Tool (SBST)(24 weeks)