Modulation of Visual-Spatial Learning in Healthy Older Adults by Transcranial Direct Current Stimulation - Proof of Principle and Mechanisms
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy Older Adults
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Performance in LOCATO task (Visual-Spatial learning and memory) after a combination of intensive visual-spatial training and tDCS
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The aim of this study is to investigate whether a combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) leads to an improvement of learning and memory in healthy older adults and to examine the underlying neuronal mechanism.
Investigators
Agnes Flöel
Prof. Dr.
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •severe internal or psychiatric disease
- •other severe neurological diseases, e.g. previous major stroke or brain tumor
- •DMS-IV manifest dementia
- •contraindication for MRT (claustrophobia, metallic implants, tattoos)
Outcomes
Primary Outcomes
Performance in LOCATO task (Visual-Spatial learning and memory) after a combination of intensive visual-spatial training and tDCS
Time Frame: immediately after the end of a 3 day training period in tDCS condition compared to sham condition
Investigation whether the combination of intensive visual-spatial training (LOCATO task) and tDCS leads to an improvement of visual-spatial learning and memory measured by performance in LOCATO task after end of a 3 day training period compared to sham stimulation.
Secondary Outcomes
- functional changes: Connectivity(after end of 3-day period of training vs baseline)
- long term effects(after 1 month vs baseline)
- Quality of life(after 1 month vs baseline)
- affective state(immediately after the end of 3-day cognitive training, after 1 month vs. baseline)
- genotyping of learning related polymorphisms(once)
- cortical excitability(at baseline)
- memory(immediately after end of 3-day of cognitive training, after 1 month vs. baseline)