Modulation of Visual-Spatial Learning in Healthy Young Adults by Transcranial Direct Current Stimulation - Proof of Principle and Mechanisms
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy Young Adults
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- performance in LOCATO task (visual-spatial learning and memory) after a combination of intensive visual-spatial training and tDCS
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The aim of this study is to investigate whether a combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) leads to an improvement of learning and memory in healthy young adults and to examine the underlying neuronal mechanism.
Investigators
Agnes Flöel
Prof. Dr.
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •right handednesss
- •unobtrusive neuropsychological screening
- •age: 18-35 years
Exclusion Criteria
- •severe internal or psychiatric disease
- •other severe neurological disease, e.g. previous major stroke, brain tumor
- •DMS-IV manifest dementia
- •contraindication for MRT (claustrophobia, metallic implants, tattoos)
Outcomes
Primary Outcomes
performance in LOCATO task (visual-spatial learning and memory) after a combination of intensive visual-spatial training and tDCS
Time Frame: immediately after end of a 3 day period of training in tDCS condition vs sham condition
Investigation whether the combination of intensive visual-spatial training (LOCATO task) and tDCS leads to improvement of visual-spatial learning and memory measured by the performance in LOCATO task after end of a 3 day period of training compared to sham stimulation.
Secondary Outcomes
- long term effects(after 1 month vs baseline)
- functional changes: Connectivity(after end of 3-day cognitive training vs baseline)
- cortical excitability(at baseline)
- Quality of Life(after 1 month vs baseline)
- memory(immediately after end of 3-day of cognitive training, after 1 month vs. baseline)
- genotyping of learning related polymorphisms(once)