Genetic Influence on Statin Pharmacodynamics

Withdrawn

• Conditions: Hypercholesterolemia; Hyperlipidemia; Dyslipidemia

• Registration Number: NCT01569854
• Lead Sponsor: Ohio State University

Brief Summary

The study intends to investigate whether genetics influence how individuals respond to statins (clinical outcomes and changes in carotid intimal media thickness)

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2012-03-30
• Study First Submitted QC: 2012-03-30
• Study First Posted: 2012-04-03
• Primary Completion: 2016-03
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-26
• Last Update Posted: 2016-09-27
• Study Completion: 2022-03

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• recently (within past 3 months) started taking atorvastatin, lovastatin, or simvastatin

Exclusion Criteria

• concomitant uses of medications, supplements, or OTCs known to interfere with statin metabolism

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
carotid intimal media thickness (CIMT)	2 years	CIMT measurements will be performed at baseline (within 3 months of starting statin) and at 6, 12, 18, and 24 months. Change in CIMT is considered a surogate measure of atherosclerotic progression.

Trial Locations

Locations (1)

Ohio State University Medical Center; 🇺🇸 Columbus, Ohio, United States