A comparative study between nebulized magnesium sulphate and dexmedetomidine for attenuation of hemodynamic response to larngoscopy and endotracheal intubation a double blinded randomized control study
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To compare the alteration in heart rate from baseline pre nebulization to 1 minute after intubation in response to laryngoscopy and endotracheal intubation
研究概览
简要总结
During laryngoscopy and endotracheal inubation, patients may have increase in heart rate and blood pressure. To attenuate this response we are using 2 drugs namely Dexmedetomidine and Magnesium sulphate in a nebulized form. This study aims to compare between Dexmedetomidine and Magnesium sulphate. Magnesium sulphate inhibits catecholamine release from adrenal glands, reduces serum epinephrine and cause decrease in atrial contraction, bradycardia and vasodilation
Dexmedetomidine has sympatholytic,sedative, amnestic, analgesic effects
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Between 18 and 60 years ASA grade 1 and 2 Modified mallampatti grading 1 and 2.
排除标准
- •known case of drug allergies uncontrolled hypertension pregnant patients.
结局指标
主要结局
To compare the alteration in heart rate from baseline pre nebulization to 1 minute after intubation in response to laryngoscopy and endotracheal intubation
时间窗: 0 min, 1 min
次要结局
- To observe the alteration in heart rate at other time points and observe alteration in systolic blood pressure, diastolic blood pressure, mean arterial pressure at(HR-2 min after intubation,5min after intubation, 10 min after intubation)
研究者
P Abenaya
Sri Venkateshwaraa medical college hospital and research center