europhysiological basis of effects of oxytocin on emotional processing and social cognition in people at ultra-high risk for psychosis.

King's College London0 sites30 target enrollmentMarch 17, 2023

Overview

2020 Other publications in https://pubmed.ncbi.nlm.nih.gov/32655132/ Intranasal oxytocin increases heart-rate variability in men at clinical high risk for psychosis: a proof-of-concept study (added 15/03/2023) 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/30626906/ Oxytocin modulates hippocampal perfusion (added 15/03/2023) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32572020/ Oxytocin on brain activation during inferring others’ beliefs and social emotions (added 15/03/2023) 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/30928180/ Oxytocin on glutamate and other metabolites (added 15/03/2023)

Registry

who.int

Start Date

March 17, 2023

End Date

October 17, 2017

Last Updated

3 years ago

Study Type

Interventional

Sex

Male

Sponsor

•Among the new referrals to the OASIS service, South London and Maudsley NHS Foundation Trust, we will enroll those meeting inclusion criteria for a UHR state for psychosis (as defined on the CAARMS revised version questionnaire).

•1\. Personal history of psychotic illness (i.e. schizophrenia, schizoaffective disorder or related psychosis)
•2\. Aged below 18 years old
•3\. Aged over 35 years old
•4\. Significant cognitive deficit (IQ\<60 as measured by the shortened WAIS)
•5\. Significant history of drug or alcohol misuse or dependence
•6\. Severe neurological and medical conditions
•7\. Evidence of hyponatremia in participant's recent blood test
•8\. Rejection of informed consent
•9\. Pregnancy (apply to women of childbearing age)
•10\. Breastfeeding (applies to women of childbearing age)