Effects of advanced platelet-rich fibrin on post-operative outcomes following wisdom teeth surgery

Not Applicable

Completed

• Conditions: post-operative complications following impacted mandibular wisdom teeth surgeries; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Surgery - Other surgery

• Registration Number: ACTRN12620000937910
• Lead Sponsor: Dr Jesslyn Praganta

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-09-21
• Study Completion: 2021-07-25
• Last Update Posted: 31 January 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

16-40 years of age (inclusive)
-Healthy patients (ASA I or ASA II)
-Requires removal of bilateral symmetrically impacted mandibular third molars
-Consents to having IVS and LA for the third molar surgery

Exclusion Criteria

-Patients with known systemic disorders such as cardiac, hepatic, endocrine, renal or
bleeding disorders that are deemed to be classified as ASA III and ASA IV
-Patients on anticoagulant / antiplatelet therapy
-Patients who received dental treatment or surgery in the past 4 weeks
-Patients who are allergic to or cannot tolerate paracetamol, non-steroidal anti-
inflammatory drugs, codeine, corticosteroids, or adrenaline-containing lignocaine
-Pregnant or lactating patients
-Pre-existing local infection with associated swelling around third molars
-Patients refusing to undergo IVS&LA, be involved in the study and/or unable to attend
follow-up appointments

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
facial swelling will be assessed by scanning the face using 3-dimensional volumetric morphometric imaging software (3dMDtrio system).[post-operative day 2 (primary timepoint) and day 7];post-operative pain will be analysed using 100mm visual analogue scale.[Post-operative pain will be measure daily from post-operative day 1-7, with assessment on day 2 being primary timepoint.<br>]

Secondary Outcome Measures

Name	Time	Method
Incidence of dry socket.<br>The original dental surgeon who did the surgery will also be the one doing the review. Dry socket will be diagnosed if there is severe postoperative pain surrounding the alveolus after post-operative day 2 (pain greater than 70/100 on a 100mm visual analogue scale) that does not improve with analgesics onboard, followed by partial or total clot loss in the interior of the alveolus, with or without halitosis. <br>If there are signs of acute infection of the socket, e.g. pus/suppuration, then the socket will be diagnosed as infected instead of dry socket. [anytime in the 7 days following surgery]