Efficacy of Intraoperative autologous platelet rich plasma injection during carpal tunnel release. A double-blind, randomized controlled trial

Phase 3

Recruiting

• Conditions: Moderate to severe carpal tunnel syndrome patients requiring carpal tunnel release surgery; carpal tunnel syndrome; severe carpal tunnel syndrome; carpal tunnel release; platelet-rich plasma; PRP

• Registration Number: TCTR20220915001
• Lead Sponsor: Faculty of medicine, Siriraj hospital, Mahidol university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-09-15
• Study Completion: 2023-10-18
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

1. Age more than 18 years old
2. Diagnosed with carpal tunnel syndrome using criteria of 2/2 1. Pain or numbness at thumb index middle and radial half of ring finger 2. a positive physical examination of Tinel's sign or Phalen test, or Durkan test
3. Electrodiagnostic confirmed with moderate to severe carpal tunnel syndrome according to American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) guideline
4. Persist symptoms at least 3 months after conservative treatment and requiring carpal tunnel release surgery

Exclusion Criteria

1. Previous PRP or steroid injection in 6 months
2. History of Inflammatory joint disease e.g. RA, SLE, gouty arthritis
3. History of Peripheral neuropathy, Cervical spondylosis radiculopathy
4. Previous fracture/injury or surgery on the affected hand
5. Cognitive impairment
6. History of Thrombocytopenia or Thrombocytosis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thai version BCTQ 3 month Thai version boston carpal tunnel questionaire (BCTQ)