The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM

Recruiting

• Conditions: Arteriovenous Malformation of Central Nervous System; Aneurysm, Ruptured; Aneurysm Cerebral; Aneurysmatic Subarachnoid Haemorrhage

• Registration Number: NCT07050381
• Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University

Brief Summary

AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-02-10
• Status Verified: 2025-06
• Study Start: 2025-06-13
• Study First Submitted QC: 2025-06-25
• Last Update Submitted: 2025-06-25
• Study First Posted: 2025-07-03
• Last Update Posted: 2025-07-03
• Primary Completion: 2025-08-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT
2. No history of stroke, Marfan syndrome, polycystic kidney disease

Exclusion Criteria

1. pAVM without flow-related aneurysms
2. Absence of clinical data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
characteristics of flow-related aneurysm	From enrollment to the end of treatment at 8 weeks	size ratio(aneurysm depth (mm)/parent artery diameter (mm))

Trial Locations

Locations (2)

Jiangsu Province Hospital; 🇨🇳 Nanjing, Jiangsu, China

the First Affiliated Hospital of Nanjing Medical University; 🇨🇳 Nanjing, Jiangsu, China