跳至主要内容
临床试验/NCT07050381
NCT07050381招募中不适用

Risk Factors Related to Rupture Flow-related Aneurysms in Posterior Arteriovenious Malformation: A Muti-center Observentional Research.

The First Affiliated Hospital with Nanjing Medical University2 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2025年6月13日最近更新:

试验速览

阶段
不适用
状态
招募中
入组人数
200
试验地点
2
主要终点
characteristics of flow-related aneurysm

研究概览

简要总结

AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

性别
All
接受健康志愿者

入选标准

  • pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT
  • No history of stroke, Marfan syndrome, polycystic kidney disease

排除标准

  • pAVM without flow-related aneurysms
  • Absence of clinical data

结局指标

主要结局

characteristics of flow-related aneurysm

时间窗: From enrollment to the end of treatment at 8 weeks

size ratio(aneurysm depth (mm)/parent artery diameter (mm))

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Lu Hua

professor

The First Affiliated Hospital with Nanjing Medical University

研究点 (2)

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