Portsmouth CORE-D Routine Care Data Repository

Recruiting

• Conditions: Adult Hospital Patients at Risk of Adverse Outcomes

• Registration Number: NCT04983082
• Lead Sponsor: Portsmouth Hospitals NHS Trust

Brief Summary

An integrated database of depersonalised routine hospital patient data consisting of demographic and disease attributes, physiological or laboratory measurements, care contacts and interventions along with associated clinical outcomes. The database is an essential resource for the development and testing of risk models and classification systems, modified as necessary for patient subgroups, which can then be introduced into clinical care to improve patient outcomes. It can also be used for large scale simulations to evaluate interventions.

Detailed Description

The aims and objectives of this database of depersonalised routinely collected hospital patient data are to:

* Conduct epidemiological and observational studies of acute hospital care.

* Develop and use algorithms and risk models to identify the deteriorating / sick adult so that interventions and enhanced care can be provided in a timelier manner with consequent resource and outcome improvements. This covers both the deteriorating inpatient at risk of adverse outcomes and people in the local community at risk of hospitalisation or in need of other health services.

* Retrospectively evaluate interventions e.g. impact of system-wide clinical pathway introduction

* Conduct simulations of clinical pathways

Study Timeline

• Study First Submitted: 2021-06-23
• Study First Submitted QC: 2021-07-27
• Study First Posted: 2021-07-30
• Study Start: 2021-08-19
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-06
• Last Update Posted: 2023-04-07
• Primary Completion: 2026-04
• Study Completion: 2026-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 750000

Inclusion Criteria

• Adult presenting at the acute hospital or receiving services from the hospital

Exclusion Criteria

• Adults who have registered an opt out of research with National Health Service (NHS) Digital
• Adults who have contacted the hospital to ask that their records are not to be included in this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In-hospital death	30 days after admission	Death during hospital admission
Unanticipated ICU admission	30 days after admission	Unanticipated ICU admission during hospital stay
Cardiac arrest	30 days after admission	Cardiac arrest during hospital stay

Secondary Outcome Measures

Name	Time	Method
Diagnosis of Corona Virus Disease (COVID) infection	At 48 hours after an observation assessment or physiological measurement	Diagnosis of COVID-19
Detection of Acute Organ Dysfunction	30 days after presentation	Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score

Trial Locations

Locations (1)

Queen Alexandra Hospital; 🇬🇧 Portsmouth, Hampshire, United Kingdom