Prevention With Oleanolic Acid of Insulin Resistance

Not Applicable

Completed

• Conditions: Metabolic Syndrome; Insulin Resistance
• Interventions: Other: Olive oil; Other: Functional olive oil

• Registration Number: NCT05049304
• Lead Sponsor: Universidad de Granada

Brief Summary

Oleanolic acid (OA), a triterpene that is highly present in olive leaves, has been proposed as component of functional foods in the prevention of metabolic syndrome due to its anti-inflammatory activity. In this research project we will study the presence of OA in postprandial TRL in healthy adolescents and in normal weight. Moreover, THP-1 macrophages will be incubated with LPS for 48h after pretreatment with OA at different concentrations. Also, TRL will be isolated from healthy adolescents before and 2 and 5h postprandially after the intake of a meal containing the functional olive oil or common olive oil and incubated with THP-1 macrophages.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Primary Completion: 2020-09-14
• Study Completion: 2021-07-30
• Status Verified: 2021-09
• Study First Submitted: 2021-09-10
• Study First Submitted QC: 2021-09-10
• Last Update Submitted: 2021-09-10
• Study First Posted: 2021-09-20
• Last Update Posted: 2021-09-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

-Participants without digestive, metabolic or oncologic disorders or any other pathology

Exclusion Criteria

-Not having the informed consent signed by the parents

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Olive oil not enriched in OA	Olive oil	-
OA-enriched functional olive oil	Functional olive oil	-

Primary Outcome Measures

Name	Time	Method
Pro-inflammatory cytokines	One year	The pro-inflammatory cytokines were studied in THP-1 macrophages stimulated with postprandial triglyceride-rich lipoproteins

Trial Locations

Locations (1)

Faculty of Health Sciences (University of Granada); 🇪🇸 Granada, Spain