Glycocalyx and Microcirculation in Sepsis

Completed

• Conditions: Sepsis
• Interventions: Other: Microcirculation and Glycocalyx assessment

• Registration Number: NCT03960307
• Lead Sponsor: University Hospital Muenster

Brief Summary

The aim of this observative, prospective study with cross-sectional design is to explore possible correlations/associations between microcirculation parameters and sublingual endothelial glycocalyx in sepsis. Therefore, 30 critically ill septic patients and 10 healthy controls were enrolled.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-01
• Primary Completion: 2017-09-30
• Study Completion: 2017-09-30
• Status Verified: 2019-05
• Study First Submitted: 2019-05-13
• Study First Submitted QC: 2019-05-21
• Study First Posted: 2019-05-23
• Last Update Submitted: 2023-09-07
• Last Update Posted: 2023-09-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy controls	Microcirculation and Glycocalyx assessment	Apparently healthy controls (n=10)
Septic patients	Microcirculation and Glycocalyx assessment	ICU patients with resuscitated sepsis, based on the sepsis-3 criteria. (n=30)

Primary Outcome Measures

Name	Time	Method
Correlations between Perfused Boundary Region (PBR) and Proportion of Perfused Vessels (PPV) measured sublingually	During ICU stay, an average of 2 days after sepsis onset	Glycocalyx thickness will be measured with PBR (in μm) and PPV will be assessed in percentage. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).
Correlations between Perfused Boundary Region (PBR) and Perfused Vessel Density (PVD) measured sublingually	During ICU stay, an average of 2 days after sepsis onset	Glycocalyx thickness will be measured with PBR (in μm) and PVD will be assessed in mm/mm\^2. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).
Correlations between Perfused Boundary Region (PBR) and Microvascular Flow Index (MFI) measured sublingually	During ICU stay, an average of 2 days after sepsis onset	Glycocalyx thickness will be measured with PBR (in μm) and MFI will be assessed in points. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).

Trial Locations

Locations (1)

Universitiy Hospital Muenster; 🇩🇪 Muenster, Germany