The effects of intermittent hypoxic training on physiological variables in cardiovascular risk persons
- Conditions
- Hypertension stage 1,dyslipidemia,overweight or obeseHypoxicator,blood pressure,lipids profile
- Registration Number
- TCTR20200605007
- Lead Sponsor
- Research Affairs, Faculty of Medicine, Khon Kaen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 45
1. Patients age between 30 to 59 years old;
2. Patients with stage I hypertension (a blood pressure of 140-159/90-99 mm Hg and of unknown cause) diagnosed by medical specialists according to the JNC8 guidelines in spited of concurrent use of antihypertensive agents;
3. Patients with LDL-C ≥ 130 mg/dL according to NCEP ATP III (2001);
4. Patients have body mass index ≥ 23 kg/m2 in overweight, ≥ 25 kg/m2 in obese according to Asia-Pacific guideline (2008);
5. Patients had to be under optimal medication treatment for at least six months;
6. Patients had to be clinically stable (i.e. no crises or changes in medication) for at least three months
1. Patients have a serious respiratory disorder (e.g. asthma, COPD);
2. Patients have a history of cardiovascular diseases (e.g. acute myocardial infarction, and/or unstable angina), history of heart failure and stroke;
3. Patients presenting with history of neuromuscular and musculoskeletal diseases for more than one month;
4. Patients have chronic kidney disease (stage I or more);
5. Patients have type II diabetes mellitus;
6. Patients presenting with endocrine disorders (e.g. hyperthyroidism, hypothyroidism);
7. Woman in pregnancy and lactation;
8. Patients had to be continuous exposure for more than one week to altitudes above 1,000 m during the three months preceding inclusion in the study;
9. Patients who participate in the weight loss program or use of weight loss drugs;
10. Patients with psychology signs and symptoms (e.g. anxiety, depression)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Body composition 3 times (pre-test, post-test 1, post-test 2) Body composition measured by bioelectrical impedance analysis machine (ioi model 353),Blood pressure 3 times (pre-test, post-test 1, post-test 2) blood pressure was measured by autonomic blood pressure mornitor., lipid profile 2 times (pre-test, post-test 1) 3 mL of venous blood samples from an antecubital vein was collected after overnight fast from 8:00, lipid profiles 2 times (pre-test, post-test 1) 3 mL of venous blood samples from an antecubital vein was collected after overnight fast from 8:00 f,Blood pressure 3 times (pre-test, post-test 1, post-test 2) blood pressure was measured by autonomic blood pressure mornitor.
- Secondary Outcome Measures
Name Time Method Heart rate and pulse oxygen saturation 3 times (pre-test, post-test 1, post-test 2) Heart rate and pulse oxygen saturation were monitored during hypoxic training by a pulse oximeter.,Lung function 3 times (pre-test, post-test 1, post-test 2) Lung function was assessed using a Vitalograph pneumotrac (Vitalograph, Ireland),Heart rate variability 3 times (pre-test, post-test 1, post-test 2) The measurement analysis of heart rate variability was using a device (SA-3000; Medicore),Muscle endurance (six-minute walk test: 6-MWT) 3 times (pre-test, post-test 1, post-test 2) the six-minute walk test was measured of distance walk over a span of 6 minutes.,Hematological variables 2 times (pre-test, post-test 1) 3 mL of venous blood samples from an antecubital vein was collected for complete blood count.