Characterization of Beta Cell Failure
- Registration Number
- NCT00869102
- Lead Sponsor
- University Hospital Tuebingen
- Brief Summary
The purpose of this study is to characterise beta cell function in subjects who despite taking part in a diabetes prevention program (life style intervention with diet and exercise) exhibit impaired glucose tolerance and beta cell dysfunction.
- Detailed Description
We have identified a subgroup of individuals with a good compliance to lifestyle intervention to prevent diabetes who lose body weight and increase insulin sensitivity, however they remain impaired glucose tolerant. These individuals show a deterioration in insulin secretory function.
We will identify a highly selected group of subjects with prediabetes that displays a large defect in insulin secretory function.We will study 50 individuals who display these characteristics and 50 subjects who do not display these characteristics. Their insulin secretion capacity in response to different secretagogues (glucose, GLP-1, arginine) will be studied. We expect to detect new pathophysiologic aspects that lead to beta cell failure particularly in this group.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- Impaired glucose tolerance
- BMI 16-40 kg/m²
- chronic disease
- anemia
- therapy with insulin or cortisone
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description GLP-1 GLP-1 -
- Primary Outcome Measures
Name Time Method Insulin secretion 1 day
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Tübingen
🇩🇪Tübingen, Germany