The Effect of Sildenafil on Sleep-Disordered Breathing in Obese Patients With Sexual Dysfunction

• Conditions: Sildenafil; Sleep Apnea; Sexual Dysfunction; Obesity

• Registration Number: NCT00893191
• Lead Sponsor: Assaf-Harofeh Medical Center

Brief Summary

Sildenafil has been shown to aggravate sleep-disordered breathing in patients with severe obstructive sleep apnea. The aim of the present study is to examine the frequency of sleep-disordered breathing in obese patients who are candidates for treatment with sildenafil for sexual dysfunction. In addition we wish to assess the effect of sildenafil on sleep-disordered breathing.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-05
• Study Start: 2009-05
• Study First Submitted: 2009-05-03
• Study First Submitted QC: 2009-05-04
• Last Update Submitted: 2009-05-04
• Study First Posted: 2009-05-05
• Last Update Posted: 2009-05-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

• Age - 40-65 years
• BMI equal to or over 30

Exclusion Criteria

• A known cardiorespiratory, liver or kidney disease
• Treatment with nitrates or alfa blockers
• Performed polysomnography in the past

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
apnea hypopnea index after sildenafil vs. placebo	Hours

Secondary Outcome Measures

Name	Time	Method
Sleep parameters (latency, efficiency etc) following sildenafil vs. placebo	hours

Trial Locations

Locations (1)

Asaf Harofeh Medical Center; 🇮🇱 Zerifin, Israel