Comparison of intraoperative cortisol level after preoperative hydrocortisone administration versus placebo in patients with normal hypothalamic-pituitary-adrenal axis undergoing transsphenoidal removal of nonfunctioning pituitary adenoma
Not Applicable
- Conditions
- Neoplasms
- Registration Number
- KCT0002426
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
The patients with nonfunctional pituitary adenomas scheduled for TSA surgery at 8 am at the Seoul National University Hospital, whose morning cortisol levels were normal (over 5 ug / dL) or insulin tolerance test or rapid ACTH test (peak> 18ug / DL).
Exclusion Criteria
? functional pituitary tumor
? pituitary apoplexy
? steroid users within the last 3 months
? steroid treatment for other reasons during surgery (cerebral edema, visual loss, airway edema, nausea / vomiting, minimal residual gland visualized)
? taking drugs affecting the HPA axis (oral pill, etomidate, ketoconazole, metyrapone, mitotane, tyrosine kinase inhibitors, megestrol, anticoagulants)
? previous brain or adrenal gland operation history
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method serum cortisol level
- Secondary Outcome Measures
Name Time Method serum ACTH level;serum glucose level;cardiovarcular collapse (SBP < 80mmHg or HR > 120 or HR < 40) incidence, duration;steroid treatment and cause;steroid dependency