Akrinor versus phenylephrin for the treatment of maternalhypotension during caesarean sectio
- Conditions
- I95.2Hypotension due to drugs
- Registration Number
- DRKS00025795
- Lead Sponsor
- niversitätsklinikum Freiburg
- Brief Summary
852 data sets could be included: n=440 Akrinor, n=412 in the phenylephrine cohort. During caesarean section blood pressure was slightly higher in the phenylephrine group compared with the Akrinor group, while hypotension <100 mm Hg systolic blood pressure (SBP) occurred significantly more often during arrival at the IMC after surgery when phenylephrine was used. Heart rate was lower and rescue medication was significantly more frequently given in the phenylephrine cohort. Irrespective of the medication used, women with baseline levels of <120 mm Hg SBP had a high risk to develop hypotension <100 mm Hg after spinal anaesthesia for caesarean section. While there was no statistical difference in mean umbilical arterial pH levels, the incidence of acidosis, defined as pH <7.2, was significantly higher with phenylephrine. Phenylephrine was not superior to Akrinor to treat spinal anaesthesia-induced maternal hypotension during caesarean section.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 852
pregnancy and sectio caesarea in spinal anesthesia
none
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method maternal hypotension, fetal pH and BE
- Secondary Outcome Measures
Name Time Method heart beat, volume recusitation, use of rescue medication, blood loss