Comparative Interest of Transcranial Doppler and Quantitative Pupillometry as Neurological Prognostic Factors at 12 Months in Brain Damaged Patients (Stroke or Head Trauma) Admitted to Intensive Care Unit
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Brain Damage
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
- Enrollment
- 73
- Locations
- 1
- Primary Endpoint
- Modified Rankin Score (mRS) (0-5)
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Transcranial Doppler is performed daily in Intensive Care Unit in brain damaged patients. For a few years now, the measurement of the photomotor reflex by quantitative Pupillometry has been routinely performed in Intensive Care Units. The objective of this work is to see if Transcranial Doppler recorded parameters and Pupillary parameters are correlated to the neurological prognosis evaluated at 9 months by the Modified Rankin Score (mRS) and the Glasgow Outcome Scale Extended (GOS-E).
Investigators
Eligibility Criteria
Inclusion Criteria
- •All brain damaged patients (stroke or head trauma)
- •Admitted to Intensive Care Unit since December 1, 2020
Exclusion Criteria
- •Refusal by the patient or his/her legal representative.
- •Benefiting from legal protection
Outcomes
Primary Outcomes
Modified Rankin Score (mRS) (0-5)
Time Frame: Year: 1
Modified Rankin Score (mRS) measures the degree of disability following a stroke in a patient (level 0 for patients with no symptoms to level 5 for patients with major disability and total dependency)..
Glasgow Outcome Scale Extended (GOS-E) (1-8)
Time Frame: Year: 1
Glasgow Outcome Scale Extended (GOS-E) measure the impact of brain injured (minimum at 1 (Dead) and maximum at 8 (Upper Good Recovery).
Secondary Outcomes
- Mean Systolic Velocity (VMS)(At inclusion)
- Intra-Cranial Pressure (ICP)(At inclusion)
- Pulsatility Index (PI)(At inclusion)
- Tele-Diastolic Velocity (TDV)(At inclusion)
- Basic pupil diameter(At inclusion)
- Percentage of variation of the pupil diameter(At inclusion)
- Latent and slope of the standard photomotor reflex(At inclusion)
- Tissue Partial Oxygen Pressure (PtiO2)(At inclusion)
- Bispectral Index (BIS)(At inclusion)
- Richmond Agitation-Sedation Scale (RASS)(At inclusion)
- Heart rate(At inclusion)
- Blood pressure(At inclusion)
- Natremia (mmol/l)(At inclusion)
- Glycemia (mmol/l)(At inclusion)